麻豆视频

Ramaley N384
Department of Integrative Physiology
University of Colorado
Boulder, CO 80309-0354
phone: 303-735-4364

Research Interests

• The Reproductive Endocrinology Laboratory听is interested in understanding how hormones from the brain and pituitary control puberty, male and female reproduction, and reproductive senescence. We are particularly interested in the function of gonadotropin-releasing hormone (GnRH) and the developmental regulation of neurons that produce GnRH, since developmental abnormalities in these neurons lead to absent puberty and infertility in all vertebrates including humans. Additional projects include investigating (1) the evolutionary pattern of GnRH using molluscan models, and (2) the developmental regulation of the endocrine hypothalamus.

Personnel

• Laboratory Director: Pei-San Tsai, Ph.D.
• Graduate Students: Tyler Akonom, M.S.,听Surayut Kluaiphanngam, B.S., Nora Want, B.A.
• Undergraduate Students:听Leah Carter, Adriana Espinoza, McKenzie Jones,听Kylie Turner.
• Collaborators: Seth Finklestein, M.D., Recovery Therapeutics,听Inc.; Dan Medeiros, Ph.D., 麻豆视频; Nelly Pitteloud, M.D., University of Lausanne; Stacia Sower, Ph.D., University of New Hampshire at Durham.

Current Research Projects

• Development and maintenance of the reproductive brain.
• Functional and structural evolution of gonadotropin-releasing hormone superfamily.
• Etiology of infertility in humans.
• Embryonic development of the neuroendocrine hypothalamus.

Opportunities for Undergraduates

• The requirements for undergraduate research in the Tsai lab are included听below.听We encourage highly motivated students, including听underrepresented and underserved students, to apply.
  • Junior or senior status.
  • Minimum commitment of one year.
  • Be able to work at least 8 hours per week.
  • Either have completed or be concurrently enrolled in IPHY 3410 (Human Anatomy) or IPHY 3470/3480 (Human Physiology).
  • Participate in a funding mechanism (such as UROP, Uplift, or IPHY Research Award)听or enroll in independent study (IPHY 4860).
• For more information, contact Prof. Tsai (pei-san.tsai@colorado.edu).

Recent Publications

• Fodor I, Zrinyi Z, Horv谩th R, Urb谩n P, Herczeg R, B眉ki G, Koene JM,听罢蝉补颈听笔-厂, Pirger Z. Identification, presence, and possible multifunctional regulatory role of invertebrate gonadotropin-releasing hormone/corazonin molecule in the great pond snail (Lymnaea stagnalis).听General and Comparative Endocrinology听299: 113621, 2020.
• Dela Cruz C, Horton CA, Sanders KN, Andersen ND,听Tsai P-S.听Conditional Fgfr1 deletion in GnRH neurons leads to minor disruptions in the reproductive axis of male and female mice.听Frontiers in听Endocrinology听11: 588459, 2021
• Laphyai P, Kruangkum T, Chotwiwatthanakun C, Semchuchot W, Thaijongrak P, Sobhon P,听Tsai P-S, Vanichviriyakit R.听Suppression of a novel vitellogenesis-inhibiting hormone significantly increases ovarian vitellogenesis in the black tiger shrimp, Penaeus monodon.听Frontiers in听Endocrinology听12: 760538, 2021
• Chung WC,听Tsai P-S.听The initiation and maintenance of gonadotropin-releasing hormone neuron identity in congenital hypogonadotropic hypogonadism.听Frontiers in听Endocrinology听14: 1166132, 2023
• Tsai P-S, Sanders KN, Dai X, Plachetzki D. Authentication of a lophotrochozoan adipokinetic hormone receptor in a gastropod, Aplysia californica.听General and Comparative Endocrinology听345:114393, 2024

Funding

• 2016-2023, NIH, "Postnatal Plasticity in the GnRH System"