Loren Hough Portrait
Associate Professor
Physics
hough@colorado.edu
(303) 735-0529

翱蹿蹿颈肠别:听DUAN F527

Research Interests:

Professor Hough currently studies intrinsically disordered proteins using solution NMR. Proteins containing disordered domains perform many important cellular functions. The aggregations of this family of proteins is implicated in neuodegenerative diseases such as Alzheimer's and Parkinson's diseases. he has developed in-cell nuclear magnetic resonance techniques to study the disordered proteins that form the selective barrier of the nuclear pore complex. He is currently extending this in-cell method to study similar proteins, especially those involved in transcriptional regulation.

Selected Publications:

  1. "The role of competition in karyopherin-FG Nup interactions; a key to efficient transport through the nuclear pore complex", Jaclyn Tetenbaum-Novatt, Loren E. Hough, R. Mironska, AS McKenney, Michael Rout,听Mol Cell Proteomics听11听(5), 31-46 (May 2012).
  2. "Structure of the B4 Liquid Crystal Phase near a Glass Surface", Dong Chen, MS Heberling, M. Nakata, Loren E. Hough, JE Maclennan, MA Glaser, E. Korblova, DM Walba, J. Watanabe, Noel A. Clark,听ChemPhysChem听13, 155-159 (Jan 2012).
  3. "Interface structure of the dark conglomerate liquid crystal phase", Dong Chen, Yongqiang Shen, Chenhui Zhu, Loren E. Hough, Nlida Gimeno, Matthew A. Glaser, Joseph E. Maclennan, M. Blanca Ros, Noel A. Clark,听Soft Matter听7, 1879-1883 (2011).
  4. "Chiral isotropic liquids from achiral molecules", Loren E. Hough, M. Spannuth, M. Nakata, D. A. Coleman, C. D. Jones, G. Dantlgraber, C. Tschierske, J. Watanabe, E. Krblova, D. M. Walba, J. E. Maclennan, M. A. Glaser, N. A. Clark,听Science听24, 452-456 (July 2009).
  5. "Helical nanofilament phases", L. E. Hough, H. T. Jung, D. Krerke, M. S. Heberling, M. Nakata, C. D. Jones, D. Chen, D. R. Link, J. Zasadzinski, G. Heppke, J. P. Rabe, W. Stocker, E. Krblova, D. M. Walba, M. A. Glaser, N. A. Clark,听Science听24, 456-460 (July 2009).
  6. "Microtubule depolymerization by the kinesin-8 motor Kip3p: a mathematical model", L. E. Hough, A. Schwabe, M. A. Glaser, J. R. McIntosh, and M. D. Betterton,听Biophysical Journal听96, 3050 (2009).