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The Soft Tissue Bioengineering Laboratory at CU Boulder is dedicated to technology development for fundamental study and engineering of connective and cardiac tissues. We desire to provide new therapies that emerge from a careful study of basic mechanobiology, to ultimately treat the millions of people worldwide afflicted with disorders of the connective and cardiac tissues, including arthritis and fibrosis, and to promote basic quality of life in humans. Our objectives are to create new scalable and integrated imaging tools to noninvasively probe dynamic functions in tissues and cells, understand the fundamental roles of physical factors in the growth, development, and maintenance of tissues, and develop novel strategies for the repair and regeneration of tissue structure and function. Mechanics is a central theme of the lab, with our basic science focus on mechanisms of physical force regulation, systems of stress and strain transfer over hierarchical scales, relationships between force and gene expression, inverse problems, and tissue stiffness, energy storage, and tribology. Our lab routinely engages in interdisciplinary activities to solve complex interface problems, spanning multiple engineering and biology disciplines, including mechanical, electrical, micro/nanotechological, biochemical, and physiological subspecialties.

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