2015 and Earlier

Baiduc, R.R., Lee, J., Dhar, S. (2014). “Toward a test battery for differential categorization of age-related hearing loss.” JISHA, 28(2), 25-40

Anonymous — Wed, 01 Oct 2014 03:04:45 +0000

Baiduc, R.R., Lee, J., Dhar, S. (2014). “Toward a test battery for differential categorization of age-related hearing loss.” JISHA, 28(2), 25-40 Anonymous (not verified) Tue, 09/30/2014 - 21:04

Age‑related hearing loss (ARHL, or presbycusis) results from neural and/or cochlear degeneration. A taxonomy distinguishing presbycusis subtypes according to site of lesion was originally proposed by linking audiometric results to histopathological findings. In most cases, the pathology is complex and audiometry and word recognition scores (WRS) are insufficient to characterize pathologies of the auditory periphery. Several sophisticated tests of auditory function, with some specifically designed to inspect cochlear or neural status (e.g., distortion product otoacoustic emissions [DPOAEs] and auditory brainstem response [ABR]) are available but not in routine use to distinguish between presbycutic subtypes. There are no in vivo methods in place to identify contributing pathologies and their relative dominance in individual instances of presbycusis. However, the promise of upcoming therapies (genetic, pharmaceutical, etc.) cannot be realized without accurate identification of presbycusis subtypes. The goal of the present study was to investigate possible improvements in differential categorization of presbycutic subtypes. We explored a test battery composed of behavioral (audiometry and speech testing) and physiological (ABR, DPOAEs, and electrocochleography) assays in presbycutic ears to ask if improvements beyond the “gold standard” (behavioral thresholds through 8 kHz and word recognition) are possible. Data from 10 hearing impaired (HI) individuals were compared to those from 21 normal hearing (NH) adults. Exploratory factor and hierarchical cluster analyses (EFA and HCA respectively) were used to evaluate phenotyping strategies. The EFA revealed three factors (highest audible frequency (HAF), pure‑tone average (PTA), and 2f1 ‑f2(High) DPOAEs) that accounted for most of the variability in hearing outcomes among the 31 participants. Hierarchical cluster analysis using the gold standard and enhanced multivariate approach revealed: (1) The clinical gold standard distinguished NH and HI participants, but failed to find commonalities among individuals with similar hearing profiles and (2) The enhanced test battery grouped participants with similar profiles, presumably indicating an underlying relationship in pathophysiology. Model data support the feasibility of a finer‑grained categorization of presbycusis than is available in current practice, although more data are needed to understand the complexities of phenotyping.

Off

Traditional

White

Baiduc, R.R., Lee, J., Dhar, S. (2014). “Spontaneous otoacoustic emissions, threshold microstructure, and psychophysical tuning over a wide frequency range in humans.” J Acoust Soc Am, 135(1), 300-14.

Anonymous — Fri, 31 Jan 2014 03:04:26 +0000

Baiduc, R.R., Lee, J., Dhar, S. (2014). “Spontaneous otoacoustic emissions, threshold microstructure, and psychophysical tuning over a wide frequency range in humans.” J Acoust Soc Am, 135(1), 300-14. Anonymous (not verified) Thu, 01/30/2014 - 20:04

Hearing thresholds have been shown to exhibit periodic minima and maxima, a pattern known as threshold microstructure. Microstructure has previously been linked to spontaneous otoacoustic emissions (SOAEs) and normal cochlear function. However, SOAEs at high frequencies (>4 kHz) have been associated with hearing loss or cochlear pathology in some reports. Microstructure would not be expected near these high-frequency SOAEs. Psychophysical tuning curves (PTCs), the expression of frequency selectivity, may also be altered by SOAEs. Prior comparisons of tuning between ears with and without SOAEs demonstrated sharper tuning in ears with emissions. Here, threshold microstructure and PTCs were compared at SOAE frequencies ranging between 1.2 and 13.9 kHz using subjects without SOAEs as controls. Results indicate: (1) Threshold microstructure is observable in the vicinity of SOAEs of all frequencies; (2) PTCs are influenced by SOAEs, resulting in shifted tuning curve tips, multiple tips, or inversion. High frequency SOAEs show a greater effect on PTC morphology. The influence of most SOAEs at high frequencies on threshold microstructure and PTCs is consistent with those at lower frequencies, suggesting that high-frequency SOAEs reflect the same cochlear processes that lead to SOAEs at lower frequencies.

Off

Traditional

White

Baiduc, R.R., Poling, G.L., Hong, O., Dhar, S. (2013). “Clinical measures of auditory function: The cochlea and beyond,” Dis Mon, 59(4), 147-56.

Anonymous — Sun, 17 Mar 2013 03:03:43 +0000

Baiduc, R.R., Poling, G.L., Hong, O., Dhar, S. (2013). “Clinical measures of auditory function: The cochlea and beyond,” Dis Mon, 59(4), 147-56. Anonymous (not verified) Sat, 03/16/2013 - 21:03

Off

Traditional

White

Hutchinson, K.M., Alessio, H., Baiduc, R.R. (2010). "Association between cardiovascular health and hearing function: pure-tone and distortion product otoacoustic emission measures," Am J Audiol 19, 26-35.

Anonymous — Tue, 01 Jun 2010 23:46:20 +0000

Hutchinson, K.M., Alessio, H., Baiduc, R.R. (2010). "Association between cardiovascular health and hearing function: pure-tone and distortion product otoacoustic emission measures," Am J Audiol 19, 26-35. Anonymous (not verified) Tue, 06/01/2010 - 17:46 Kathleen M. Hutchinson , Helaine Alessio , Rachael R. Baiduc

<p>In this study, the association between cardiovascular health/fitness and hearing health/auditory sensitivity was examined by using pure-tone audiometry and distortion product otoacoustic emissions. Purpose: A reduction in hearing sensitivity is often considered to be a normal age-related change. Recent studies have revisited prior ways of thinking about sensory changes over time, uncovering health variables other than age that play a significant role in sensory changes. Method: In this cross-sectional study, cardiovascular (CV) health, pure-tone thresholds at 1000 to 4000 Hz, and distortion product otoacoustic emissions (DPOAEs), with and without contralateral noise, were measured in 101 participants age 10–78 years. Results: Persons in the “old” age category (49–78 years) had worse pure-tone hearing sensitivity and DPOAEs than persons in the younger age categories (p < .05), affirming an age effect. Although hearing decline occurred in all persons in all CV fitness categories of every age group, those with low CV fitness in the old age group had significantly worse puretone hearing at 2000 and 4000 Hz (p < .05). Otoacoustic emission measurements were better for the old high-fit group but not significantly influenced by CV fitness level across age groups. Conclusions: Results of the current study elucidate the potentially positive impact of CV health on hearing sensitivity over time. This finding was particularly robust among older adults.</p>

Off

Traditional

White