Commentary: Phages gain the upper hand in the metabolic arms race for NAD+
Molecular Cell (2024). PubMed PMID: .
Abstract
Bacteria often defend against phage infection by deploying NADase effectors to degrade cellular NAD+, thereby halting both bacterial growth and phage replication. In a recent article in Nature, Osterman et al.1 identify phage-encoded counterdefense pathways that reconstitute NAD+ during infection, enabling phages to combat multiple unrelated antiphage systems.
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Citation
Bullen NP, Whiteley AT. Mol Cell. 2024 Dec 5;84(23):4480-4482. doi: 10.1016/j.molcel.2024.11.017. PubMed PMID: 39642854.
Categories: Commentaries